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Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).
Formalin-fixed, paraffin-embedded Rat Stomach stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).
This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
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