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B Cell Markers Antibodies

B cells, also known as B lymphocytes, are a type of white blood cell that play a crucial role in the immune system response. They are an essential component of the adaptive immune response, responsible for producing antibodies (immunoglobulins) and serving as a critical defense mechanism against infections. B cells are a diverse group of cells that can recognize and respond to various pathogens, including bacteria, viruses, and other foreign substances.

The Role of B Lymphocyte Biomarkers

B cell identification and/or quantification, using protein biomarkers, is vital for diagnosing and monitoring various medical conditions, including autoimmune diseases, immunodeficiency disorders, and certain types of cancers, like leukemia and lymphoma. Some B cell biomarkers yield prognostic information about disease outcomes and predict cancer aggressiveness, guiding treatment decisions. In the laboratory or the clinic, monitoring B cells with biomarkers facilitates vaccine and immunotherapy efficacy studies and elucidates the underlying mechanisms of various diseases.

The choice of which B cell biomarkers to measure depends on the specific goals of the analysis and the research context. NeoBiotechnologies offers a variety of validated antibodies targeting B cell protein biomarkers that are guaranteed to yield accurate and reliable results. A list of our specific and sensitive antibodies and their intended applications is shown in the table below.

Notable B cell markers include:

  • CD19: a cell surface protein found on B cells used as a biomarker for identifying B cells.
  • CD20: a B cell surface protein commonly used in B cell-related research and clinical diagnostics.
  • Immunoglobulins (Ig): Different classes and subtypes of immunoglobulins (IgM, IgG, IgA, IgE, IgD) serve as markers of B cell activity. Measuring antibody levels can indicate the presence of specific immune responses.
  • B Cell Receptor (BCR) Components: Various components of the B cell receptor, such as CD79a and CD79b, are used as markers for B cells.
  • B-Cell Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL): cytokines that play a role in B cell survival and activation and provide information about B cell function.
  • Cytokines and Chemokines: These signaling molecules are involved in B cell activation and regulation, and their levels can be indicative of B cell activity.
  • BCL-2: B cell lymphoma 2 (BCL-2) is a protein associated with cell survival and relevant in B cell malignancies.
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