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Recombinant Cytokeratin, Type II (Epithelial Marker) Antibody [KRTH/4392R]

In Stock
Catalog Number Formulation Size Price
RBM41-4392-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
RBM41-4392-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
RBM41-4392-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed in highly specific patterns related to the epithelial type and stage of cellular differentiation. This antibody can detect high molecular weight CK1, CK2, CK3, CK4, CK5, CK6, CK7 and CK8. It is usually used in a cytokeratin cocktail with type I cytokeratins antibody.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Gene Name
Positive Control
Skin or squamous cell carcinoma.
Immunogen
Synthetic peptide corresponding to Type II Cytokeratins residues within aa300-400 of Type II Cytokeratins
Alternate Names
Keratin, type II cytoskeletal 2 oral, Cytokeratin-2P, Keratin-76, Type-II keratin Kb9, KRT2B; KRT2P; HUMCYT2A; Keratin, type II Cytoskeletal 2 oral; K76; Keratin 2p (K2P); Keratin-76; Cytokeratin-2P (CK-2P; Type-II Keratin Kb9

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
KRTH/4392R
Chromosome Location
12q13.13
Mol. Weight of Antigen
66/65/64/57/62/60/51/54kDa

Functions

  • Probably contributes to terminal cornification.

Key References

  • Spagnolo DV, et al. Am J Clin Pathol. 1985 Dec;84(6):697-704.
  • Eichner R, et al. J Cell Biol. 1984 Apr;98(4):1388-96.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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