Monocyte Markers Antibodies

Monocytes are a type of white blood cell that are part of the innate immune system. These large, circulating immune cells play a critical role in immune responses, inflammation, and tissue repair. Monocytes are produced in the bone marrow and can differentiate into macrophages or dendritic cells when they migrate into tissues. These cells are involved in the phagocytosis of pathogens, the presentation of antigens to T cells, and the secretion of inflammatory molecules.

The Role of Monocyte Markers

Monocyte biomarkers are crucial for distinguishing monocytes from other cell types in blood and tissues, which is essential for studying their roles in various immune responses and disease processes. Some of these cell biomarkers can provide information about the functional state or activation status and their roles in inflammation and immune responses. Moreover, monocyte protein biomarkers can monitor disease progression, provide prognostic information about disease outcomes, and predict tumor aggressiveness.

The choice of which monocyte cell biomarkers to measure depends on the specific goals of the analysis and the research context. NeoBiotechnologies offers a variety of validated antibodies targeting monocyte cell protein biomarkers that are guaranteed to yield accurate and reliable results. A list of our specific and sensitive antibodies and their intended applications is shown in the table below.

Notable monocyte cell markers include:

• CD14: a cell surface marker expressed on monocytes, macrophages, and dendritic cells. It is often used to identify and distinguish these cell types, especially in the context of monocytes in blood.
• CD16: a cell surface marker that can be used to distinguish subsets of monocytes. There are “classical” (CD14+ CD16-), “intermediate” (CD14+ CD16+), and “non-classical” (CD14low CD16+) monocyte subsets in circulation.
• CD11b (Integrin alpha M): expressed on the surface of monocytes and is involved in cell adhesion and immune functions.
• HLA-DR (Human Leukocyte Antigen – DR isotype): an MHC class II molecule expressed on the surface of monocytes, which is essential for antigen presentation to CD4+ T cells.
• CD64 (FcγRI): a cell surface marker expressed on monocytes. It is a high-affinity receptor for IgG antibodies and plays a role in phagocytosis.
• CCR2 (C-C chemokine receptor type 2): a chemokine receptor involved in monocyte migration to sites of inflammation or infection.
• CD115 (M-CSF Receptor): a receptor for macrophage colony-stimulating factor (M-CSF) and is involved in the development and survival of monocytes and their differentiation into macrophages.