Dendritic Cell Markers Antibodies

Dendritic cells (DCs) are a specialized type of white blood cell that plays a central role in the immune system. They are critical for initiating and regulating immune responses, serving as antigen-presenting cells (APCs) that capture, process, and present antigens to T cells. This function is essential for activating adaptive immune responses and the body’s ability to recognize and respond to infections and foreign substances. Dendritic cells are found in various tissues, including the skin, mucosal surfaces, and lymphoid organs.

The Role of DC Biomarkers

Identifying DCs and/or quantifying DC-specific proteins offers insights into the function and status of these crucial immune cells, contributing to understanding immune responses and disease pathogenesis and developing novel immunotherapies, such as dendritic cell-based immunotherapies. Some biomarkers help distinguish between immature (capturing antigens) and mature (presenting antigens to T cells) DCs, which is vital for understanding the immune response. Additionally, since changes in dendritic cell populations and their activation status indicate disease progression, these biomarkers are routinely used to monitor the progression of autoimmune disorders, infectious diseases, and cancer, guiding treatment decisions and predicting patient responses to immunotherapies.

The choice of which dendritic cell biomarkers to measure depends on the specific goals of the analysis and the research context. NeoBiotechnologies offers a variety of validated antibodies targeting dendritic cell protein biomarkers that are guaranteed to yield accurate and reliable results. A list of our specific and sensitive antibodies and their intended applications is shown in the table below.

Notable dendritic cell markers include:

• CD11c (Integrin alpha X): a cell surface marker commonly used to identify dendritic cells, especially in human blood and tissues.
• CD11b (Integrin alpha M): a cell surface marker expressed by dendritic cells, particularly in the mouse immune system.
• CD83: a marker associated with mature dendritic cells and is often used to distinguish activated dendritic cells from their immature counterparts.
• CD86 (B7-2): a co-stimulatory molecule expressed on dendritic cells and other APCs. It plays a role in T cell activation.
• CD1a and CD1c: specific to subsets of dendritic cells and are used to distinguish different dendritic cell populations.
• HLA-DR (Human Leukocyte Antigen – DR isotype): HLA-DR is an MHC class II molecule expressed on the surface of dendritic cells and is involved in antigen presentation to CD4+ T cells.
• CCR7 (C-C chemokine receptor type 7): CCR7 is a chemokine receptor upregulated on mature dendritic cells, enabling them to migrate to lymph nodes to present antigens to T cells.
• IL-12 and IL-23: Interleukin-12 (IL-12) and Interleukin-23 (IL-23) are cytokines produced by dendritic cells that play a role in shaping the immune response.