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Neuron Markers Antibodies

Neurons are the fundamental building blocks of the nervous system and are specialized cells that transmit information through electrical and chemical signals. Neurons are central in processing and transmitting information throughout the body, enabling various functions such as sensory perception, motor control, memory, and cognitive processes. Neurons consist of a cell body (soma), dendrites (which receive signals from other neurons), and an axon (which transmits signals to other neurons or target cells).

The Role of Neuron Markers

Neuron protein biomarkers are crucial for distinguishing neurons from other cell types in the nervous system, such as glial cells, and determining their activation levels, neurotransmitter profiles, and involvement in neural circuits. Some neuron biomarkers are utilized to assess neuron health, damage, and regeneration and diagnose and monitor neurological disorders and injuries. Interestingly, in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, the loss of specific neurons is a hallmark of the disease. Additionally, neuron cell biomarkers can evaluate the impact of drugs on neuronal function for developing drugs against neurological conditions.

The choice of which neuron cell biomarkers to measure depends on the specific goals of the analysis and the research context. NeoBiotechnologies offers a variety of validated antibodies targeting neuron cell protein biomarkers that are guaranteed to yield accurate and reliable results. A list of our specific and sensitive antibodies and their intended applications is shown in the table below.

Notable protein neuron cell markers include:

  • Neuron-Specific Enolase (NSE): an enzyme primarily found in neurons and neuroendocrine cells. It is often used as a biomarker in diagnosing and monitoring brain and neuronal damage.
  • Neurofilaments: structural components of neurons that are released into the bloodstream following neuronal injury. Measuring neurofilament levels can provide information about neuron damage or degeneration.
  • Tau Protein: Tau is a microtubule-associated protein that becomes hyperphosphorylated and aggregates in certain neurodegenerative diseases, such as Alzheimer’s. It is used as a biomarker for assessing tauopathies.
  • β-Amyloid (Aβ) Protein: a peptide associated with Alzheimer’s disease, and its levels in the brain or cerebrospinal fluid can be used to assess disease risk and progression.
  • GABA (Gamma-Aminobutyric Acid): the primary inhibitory neurotransmitter in the brain. Measuring GABA levels can provide information about inhibitory signaling and neuron function.
  • Glutamate: the major excitatory neurotransmitter in the brain. Assessing glutamate levels can provide insights into excitatory signaling and neuron function.
  • ChAT (Choline Acetyltransferase): an enzyme involved in acetylcholine synthesis, and its presence is used as a marker for cholinergic neurons.
  • TH (Tyrosine Hydroxylase) is an enzyme involved in synthesizing dopamine and norepinephrine, making it a marker for dopaminergic and noradrenergic neurons.
  • CNP (2′,3′-Cyclic Nucleotide 3′ Phosphodiesterase): a marker for oligodendrocytes, which are involved in myelinating axons in the central nervous system.
  • Synaptic Proteins (synaptophysin, synapsin, and PSD-95): involved in synaptic function and used to assess the health and activity of synapses, which are crucial for neuronal communication.
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