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Mast Cell Markers Antibodies

Mast cells are a type of white blood cell that are a critical component of the body’s defense against pathogens and are particularly well-known for their involvement in allergic reactions. Mast cells are found in various tissues throughout the body, especially near blood vessels and mucosal surfaces, playing a role in inflammation and immune responses.

The Role of Mast Cell Markers

Identifying mast cells and quantifying mast cell biomarkers yields valuable information about their presence, activation, and functional state under various physiological and pathological conditions. Mast cell protein biomarkers are essential for distinguishing mast cells from other cell types in tissues, as mast cells can look similar to basophils under a microscope, which is crucial for studying their roles in health and disease. In the laboratory and clinic, mast cell biomarkers are utilized for monitoring disease progression and predicting allergic responses.

The choice of which mast cell biomarkers to measure depends on the specific goals of the analysis and the research context. NeoBiotechnologies offers a variety of validated antibodies targeting mast cell protein biomarkers that are guaranteed to yield accurate and reliable results. A list of our specific and sensitive antibodies and their intended applications is shown in the table below.

Notable mast cell markers include:

  • CD117 (KIT): a cell surface receptor, also known as KIT, and is one of the most commonly used biomarkers for identifying mast cells. It plays a crucial role in mast cell development and survival.
  • FcεRI (High-Affinity IgE Receptor): a cell surface receptor expressed by mast cells. It is important for mediating allergic responses, as it binds to IgE antibodies and triggers mast cell activation in response to allergens.
  • Tryptase: an enzyme produced and stored in mast cell granules. Measuring tryptase levels can provide information about mast cell activation and the presence of mast cell-related diseases.
  • Chymase: an enzyme stored in mast cell granules and can be measured to assess mast cell activation. Chymase is especially relevant in tissues like the heart and skin.
  • CD203c (Ectonucleotide Pyrophosphatase/Phosphodiesterase 3): a cell surface marker that can be used to identify and quantify activated mast cells. Useful for monitoring mast cell activation in response to allergens.
  • CD34: a cell surface marker found on precursor cells, including mast cell precursors. It is used in research settings to identify and study mast cell progenitors.
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