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ALDH1A1 (Aldehyde Dehydrogenase 1A1) Antibody [ALDH1A1/1381]

Additional information

Catalog Number: 216-MSM1
Reactivity:

,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
216-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
216-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
216-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
ALDH1A1 (Aldehyde Dehydrogenase 1A1) Antibody

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381).

ALDH1A1 (Aldehyde Dehydrogenase 1A1) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381).

ALDH1A1 (Aldehyde Dehydrogenase 1A1) Antibody - Image 3

Western Blot of K562 and Lung lysate ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381).

ALDH1A1 (Aldehyde Dehydrogenase 1A1) Antibody - Image 4

Western Blot Analysis of human Liver tissue lysate using ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381).

ALDH1A1 (Aldehyde Dehydrogenase 1A1) Antibody - Image 5

SDS-PAGE Analysis of Purified ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381). Confirmation of Integrity and Purity of Antibody.

ALDH1A1 Antibody in Western Blot (WB)

ALDH1A1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Brain tissue lysate using ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381).

ALDH1A1 Antibody in Western Blot (WB)

ALDH1A1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Stomach, Mouse Stomach and Rat Stomach tissue lysates using ALDH1A1 Mouse Monoclonal Antibody (ALDH1A1/1381).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human, Rat
Clone
ALDH1A1/1381
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Axon, Cell projection, Cytoplasm, Cytosol
Gene Name
ALDH1A1
Positive Control
HepG2 or A549 cells. Human and Rat stomach, Colon or Testicular Carcinoma., K562, Liver, Lung, Brain
Immunogen
Recombinant fragment (around aa 315-434) of human ALDH1A1 protein (exact sequence is proprietary).
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:19296407, PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:26373694, PubMed:25450233). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:19296407, PubMed:12941160, PubMed:15623782). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
Key References
  • Xu J, Muller S., et al. Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer. Eur J Cancer. 2012 Jul;48(11):1682-91
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
216
SwissProt
P00352
Chromosome Location
9q21.13
Mol. Weight of Antigen
56kDa
Alternate Names
Aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, Acetaldehyde dehydrogenase 1; AHD2; ALDC; Aldehyde dehydrogenase 1 soluble; Aldehyde dehydrogenase 1A1; Aldehyde dehydrogenase family 1 member A1; ALDH-E1; ALDH1; ALDH1A1; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm binding protein Li 53e; HEL-S-53e; PUMB1; RALDH1; Retinal dehydrogenase 1

Summary

ALDH1A1 belongs to the ALDH enzymes, a family of evolutionarily conserved enzymes comprised of 19 isoforms that are localized in the cytoplasm, mitochondria or nucleus. ALDH1A1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Reportedly, high ALDH1A1 expression is found in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. In combination with CD34, ALDH1A1 may be useful for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.

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