CD34 is a transmembrane glycoprotein with a molecular weight of approximately 110 kDa. Posttranslational modifications, particularly glycosylation, play a significant role in shaping the structure and function of CD34.
The primary function of CD34 is to serve as a cell surface marker for hematopoietic stem and progenitor cells. It plays a crucial role in cell adhesion, migration, and differentiation. CD34 is expressed in various cells, including hematopoietic stem cells, endothelial progenitor cells, and some mesenchymal stem cells. In addition to its presence in the bone marrow and peripheral blood, CD34 is found in various tissues during embryonic development, facilitating processes like vasculogenesis.
The expression of CD34 is tightly modulated during hematopoiesis, with high levels observed on undifferentiated hematopoietic stem cells and reduced expression as cells differentiate into specific blood cell lineages. The presence of CD34 on the surface of hematopoietic stem cells makes it a valuable marker for isolating and characterizing these cells for research and clinical applications.
In human health and disease, CD34 has significant implications, particularly in the context of hematological disorders and regenerative medicine. CD34-positive cells are crucial for hematopoietic regeneration and are often used in stem cell transplantation therapies. In diseases such as leukemia, where abnormal hematopoiesis occurs, CD34 expression patterns can provide diagnostic and prognostic insights.
Antibodies targeting CD34 have extensive clinical applications, serving as valuable tools for identifying and isolating hematopoietic stem and progenitor cells. In diagnostic settings, CD34 antibodies are employed in immunohistochemistry (IHC) to detect CD34 expression in tissue samples, aiding in diagnosing hematopoietic malignancies and other disorders. Moreover, CD34 antibodies are utilized in flow cytometry to enumerate and characterize CD34-positive cells, supporting clinical decisions related to stem cell transplantation.
At Neobiotechnologies, we are dedicated to providing high-quality antibodies for researchers and clinicians studying CD34 and its applications in stem cell research, diagnostics, and therapeutic development. Explore our extensive catalog to access reliable tools for studying CD34 and contribute to regenerative medicine and hematological research advancements. Elevate your research capabilities with our cutting-edge antibodies and support the pursuit of improved diagnostics and therapeutic interventions.
Synonyms
Hematopoietic progenitor cell antigen CD34, Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin
Research Areas
Immunology, Endothelial Cell Marker, Hematopoietic Stem Cells, Mesenchymal Stem Cell Differentiation
