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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Cytokeratin 5 Recombinant Rabbit Monoclonal Antibody (KRT5/6399R).
IHC analysis of formalin-fixed, paraffin-embedded human testis. Negative tissue control using KRT5/6399R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis Purified CK5 Recombinant Rabbit Monoclonal Antibody (KRT5/6399R). Confirmation of Purity and Integrity of Antibody.
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Positive Control
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Immunogen
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Specificity & Comments
This Mab recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, yoepithelial, and mesothelium. Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express. Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.
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