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Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with Cyclin E Recombinant Rabbit Monoclonal Antibody (CCNE1/4935R).
Formalin-fixed, paraffin-embedded human endometrium stained with Cyclin E Recombinant Rabbit Monoclonal Antibody (CCNE1/4935R).
Western Blot Analysis of HCT-116 cell lysate using Cyclin E Recombinant Rabbit Monoclonal Antibody (CCNE1/4935R).
SDS-PAGE Analysis Purified Cyclin E Recombinant Rabbit Monoclonal Antibody (CCNE1/4935R). Confirmation of Purity and Integrity of Antibody.
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
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Species Reactivity
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Mol. Weight of Antigen
Specificity & Comments
Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
