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Home >> Antibodies >> CD71 / Transferrin Receptor (TFRC)

CD71 / Transferrin Receptor (TFRC)

Mouse Monoclonal Antibody [Clone TFRC/3630]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified CD71 Mouse Monoclonal antibody (TFRC/3630). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human tonsil stained with CD71 Mouse Monoclonal Antibody (TFRC/3630). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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Formalin-fixed, paraffin-embedded human placenta stained with CD71 Mouse Monoclonal Antibody (TFRC/3630). Inset: PBS instead of primary antibody; secondary only negative control.

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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with CD71 Mouse Monoclonal Antibody (TFRC/3630) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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Western blot analysis of THP-1 and Jurkat cell lysates using CD71 Mouse Monoclonal Antibody (TFRC/3630).

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Western blot analysis of PC-3 cell lysate using CD71 Mouse Monoclonal Antibody (TFRC/3630).

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Analysis of Protein Array containing >19,000 full-length human proteins using CD71 / TFRC Monospecific Mouse Monoclonal Antibody (TFRC/3630).

Product Details

Synonyms

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Positive Control

CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human TFRC receptor (exact sequence is proprietary)

Cellular Localization

Cell surface.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

85-95kDa (monomer); 190kDa (dimer)

Specificity & Comments

It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa (Workshop IV). This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Knapp et al. Leukocyte Typing IV, Oxford Univ Press, Nrs. M15, M15.1, M15.1.1, M15.2, M15.3.1, M15.3.3, M15.4.2, M15.4.3, M15.5.6, M15.5.7, M15.5.9, M16.1, P1.6 and B22.16.

Bioinformatics

  •  Entrez Gene ID: 7037
  •  Gene Symbol: TFRC
  •  SwissProt: P02786
  •  Chromosome Location: 3q29
  •  Unigene: 529618