Formalin-fixed, paraffin-embedded Human Bone Marrow stained with CD71 Rabbit Recombinant Monoclonal Antibody (TFRC/2898R).
SDS-PAGE Analysis Purified CD71 Rabbit Recombinant Monoclonal Antibody (TFRC/2898R). Confirmation of Purity and Integrity of Antibody.
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
