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CD71 / Transferrin Receptor (TFRC) Antibody [TFRC/1059]

Additional information

Catalog Number: 7037-MSM3
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
7037-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
7037-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7037-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD71 Antibody in Flow Cytometry (FC)

CD71 Antibody in Flow Cytometry (FC)

Flow Cytometry of human CD71 on Jurkat cells. Black: cells alone; Grey: Isotype Control; Green: CF488-labeled CD71 Monoclonal Antibody (TFRC/1059)

CD71 Antibody in Flow Cytometry (FC)

CD71 Antibody in Flow Cytometry (FC)

Flow Cytometric Analysis of PFA-fixed K562 cells using CD71 Mouse Monoclonal Antibody (TFRC/1059) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

CD71 Antibody in Immunofluorescence (IF)

CD71 Antibody in Immunofluorescence (IF)

Immunofluorescence Analysis of K562 cells labeling CD71 with CD71 Mouse Monoclonal Antibody (TFRC/1059) followed by goat anti-mouse IgG-CF488 (green). The nuclear counterstain is RedDot (red).

CD71 Antibody in SDS-PAGE

CD71 Antibody in SDS-PAGE

SDS-PAGE Analysis Purified CD71 Mouse Monoclonal Antibody (TFRC/1059). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Clone
TFRC/1059
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane, Cell surface, Melanosome, Secreted
Gene Name
TFRC
Positive Control
CCRF-CEM, Jurkat or K562 cells.
Immunogen
Recombinant human TFRC protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Additional information

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Reactivity:

VIEW ALL ANTIBODIES

Other Information

Functions
  • Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738).
  • (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Key References
  • K. Moolenaar et al. Cancer research 50,1102-1106, 1990.
  • Van de Rijna M, Geurts van Kessel AHM, Kroezen V, van Agthoven AJ, Verstijnen K, Terhorst C, Hilgers J: Cytogenet Cell Genet 1983;36:525-531.
  • Oudermans et al. Cancer, 1986; 58:1252.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
7037
SwissProt
P02786
Chromosome Location
3q29
Mol. Weight of Antigen
85-95kDa (monomer); 190kDa (dimer)
Alternate Names
Transferrin receptor protein 1, T9, p90, Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Summary

It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

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