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Formalin-fixed, paraffin-embedded human uterus stained with Smooth Muscle Actin Recombinant Rabbit Monoclonal (ACTA2/1614R).
Formalin-fixed, paraffin-embedded human skeletal muscle stained with Smooth Muscle Actin Recombinant Rabbit Monoclonal (ACTA2/1614R).
SDS-PAGE Analysis Purified SMA Recombinant Rabbit Monoclonal Antibody (ACTA2/1614R). Confirmation of Integrity and Purity of Antibody.
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Positive Control
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Specificity & Comments
Actin is a major component of the cytoskeleton and is present in most cell types. It is highly specific to actin from smooth muscles. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.
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