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CD79b (B-Cell Marker) Antibody [IGB/1842]

Additional information

Catalog Number: 974-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
974-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
974-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
974-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD79b (B-Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with CD79b Mouse Monoclonal Antibody (IGB/1842).

CD79b (B-Cell Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified CD79b Mouse Monoclonal Antibody (IGB/1842). Confirmation of Integrity and Purity of Antibody.

  • ELISA
  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Immunohistochemistry
Species Reactivity
Human
Clone
IGB/1842
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CD79B
Positive Control
Daudi or Ramos cells. Germinal center B- cells in a lymph node or tonsil (IHC).
Immunogen
Recombinant human CD79b protein fragment (around aa29-159) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Key References
  • Wood, W.J., Jr., et al. 1993. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). Genomics 16: 187-192.
  • Mason, D.Y., et al. 1992. The B29 and MB-1 polypeptides are differentially expressed during human B cell differentiation. Eur. J. Immunol. 22:2753-2756.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
974
SwissProt
P40259
Chromosome Location
17q23.3
Mol. Weight of Antigen
39kDa
Alternate Names
B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, AGM6; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; B29; B29/Ig-beta/CD79b; CD79b; Ig-beta; IGB; Immunoglobulin-associated B29 protein

Summary

CD79 (also designated Ig chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases.

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