SDS-PAGE Analysis Purified CD79b Recombinant Rabbit Monoclonal Antibody (IGB/2940R). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis Purified CD79b Recombinant Rabbit Monoclonal Antibody (IGB/2940R). Confirmation of Integrity and Purity of Antibody.

Printable Datasheet

Recombinant CD79b (B-Cell Marker) [IGB/2940R]

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Summary

CD79 (also designated Ig chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases.

Product Properties & Targets

Host
Rabbit
Applications
ELISA
Species Reactivity
Human
Isotype
IgG
Cellular Localization
Cell membrane
Light Chain
Kappa
Gene Name
CD79B
Positive Control
Daudi or Ramos cells. Germinal center B- cells in a lymph node or tonsil.
Immunogen
Recombinant human CD79b protein fragment (around aa29-159) (exact sequence is proprietary)
Alternate Names
B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, AGM6; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; B29; B29/Ig-beta/CD79b; CD79b; Ig-beta; IGB; Immunoglobulin-associated B29 protein

Database Links

Entrez Gene ID
974
Unigene
89575
SwissProt
P40259

Additional Information

Clone
IGB/2940R
Human Gene Symbol
CD79B
Chromosome Location
17q23.3
Mol. Weight of Antigen
39kDa

Functions

  • Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Known Applications & Suggested Dilutions

  • ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
  • Optimal dilution for a specific application should be determined.

Key References

  • Wood, W.J., Jr., et al. 1993. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). Genomics 16: 187-192.
  • Mason, D.Y., et al. 1992. The B29 and MB-1 polypeptides are differentially expressed during human B cell differentiation. Eur. J. Immunol. 22:2753-2756.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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