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Home >> Antibodies >> PTEN (Tumor Suppressor Oncoprotein)

PTEN (Tumor Suppressor Oncoprotein)

Mouse Monoclonal Antibody [Clone PTEN/2110]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with PTEN Mouse Monoclonal Antibody (PTEN/2110).

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Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with PTEN Mouse Monoclonal Antibody (PTEN/2110).

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SDS-PAGE Analysis Purified PTEN Mouse Monoclonal Antibody (PTEN/2110). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using PTEN Mouse Monoclonal Antibody (PTEN/2110).

Product Details

Synonyms

BZS; DEC; GLM2; MHAM; Mutated in Multiple Advanced Cancers 1 (MMAC1); MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Phosphatase and Tensin Homolog; Phosphatase and tensin like protein; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase; PTEN; PTEN1; TEP1

Positive Control

MCF-7 or HeLa cells. Prostate, Breast, Liver, Renal Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human PTEN protein

Cellular Localization

Cytoplasmic and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

55kDa

Specificity & Comments

PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Perren A., et al. Am J Pathol 1999; 155(4):1253-1260

Bioinformatics

  •  Entrez Gene ID: 5278
  •  Gene Symbol: PTEN
  •  SwissProt: P60484
  •  Chromosome Location: 10q23.31
  •  Unigene: 500466, 729457
NBT02110