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SDS-PAGE Analysis of Purified PTEN Mouse Monoclonal Antibody (PTEN/7345). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with PTEN Mouse Monoclonal Antibody (PTEN/7345) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control.
PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.
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