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Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85 and p85), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110 and p110 interact with p85, and p110 has also been shown to interact with p85 in vitro. p110 L expression is restricted to white blood cells. It has been shown to bind p85 and p85, but it apparently does not phosphorylate these subunits. p110 L seems to have the capacity to autophosphorylate. p110 does not interact with the p85 subunits. It has been shown to be activated by and heterotrimeric G proteins.
Key References