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PIK3R2 (Phosphoinositide-3-kinase regulatory subunit 2) Antibody [PIK3R2/1293]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes


Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85伪 and p85尾), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110伪 and p110尾 interact with p85伪, and p110伪 has also been shown to interact with p85尾 in vitro. p110 �L expression is restricted to white blood cells. It has been shown to bind p85伪 and p85尾, but it apparently does not phosphorylate these subunits. p110 �L seems to have the capacity to autophosphorylate. p110纬 does not interact with the p85 subunits. It has been shown to be activated by 伪 and 尾纬 heterotrimeric G proteins.

Product Properties & Targets

Antibody Type
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Gene Name
Positive Control
Raji or U-937 cells. Human spleen or tonsil.
Recombinant fragment of human PIK3R2 protein (around aa 520-720) (exact sequence is proprietary)
Alternate Names
Phosphatidylinositol 3-kinase regulatory subunit beta, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, p85 beta; P85B; Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta); PI3 kinase p85 beta subunit; PI3K regulatory subunit beta; PIK3R2; PtdIns-3-kinase regulatory subunit p85-beta

Database Links

Entrez Gene ID

Additional Information

Chromosome Location
Mol. Weight of Antigen


  • Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Key References

  • Vallejo-D az, Jes s et al. Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Oncotarget vol. 7,51 (2016): 85063-85078. doi:10.18632/oncotarget.13195

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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