PIK3R2 (Phosphoinositide-3-kinase regulatory subunit 2) Antibody [PIK3R2/1293]

These antibodies are validated on HuProt™ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 5296-MSM3
Gene:

Reactivity:

Host:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
5296-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5296-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5296-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • IHC

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Host
Mouse
Applications
Species Reactivity
Clone
PIK3R2/1293
Isotype
IgG2b
Light Chain
Kappa
Gene Name
Positive Control
Raji or U-937 cells. Human spleen or tonsil.
Immunogen
Recombinant fragment of human PIK3R2 protein (around aa 520-720) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Key References
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
19p13.11
Mol. Weight of Antigen
85kDa
Alternate Names
Phosphatidylinositol 3-kinase regulatory subunit beta, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, p85 beta; P85B; Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta); PI3 kinase p85 beta subunit; PI3K regulatory subunit beta; PIK3R2; PtdIns-3-kinase regulatory subunit p85-beta

Summary

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85伪 and p85尾), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110伪 and p110尾 interact with p85伪, and p110伪 has also been shown to interact with p85尾 in vitro. p110 �L expression is restricted to white blood cells. It has been shown to bind p85伪 and p85尾, but it apparently does not phosphorylate these subunits. p110 �L seems to have the capacity to autophosphorylate. p110纬 does not interact with the p85 subunits. It has been shown to be activated by 伪 and 尾纬 heterotrimeric G proteins.

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