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Home >> Antibodies >> LMO2 (B-Cell Marker)

LMO2 (B-Cell Marker)

Mouse Monoclonal Antibody [Clone LMO2/1971]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Follicular Lymphoma stained with LMO2 Mouse Monoclonal Antibody (LMO2/1971).

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Formalin-fixed, paraffin-embedded human Pancreas stained with LMO2 Mouse Monoclonal Antibody (LMO2/1971).

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Western Blot Analysis of Ramos cell lysate using LMO2 Mouse Monoclonal Antibody (LMO2/1971).

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Purified LMO2 Mouse Monoclonal Antibody (LMO2/1971). Confirmation of Purity and Integrity of Antibody.

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Flow Cytometric Analysis of K562 cells using LMO2 Mouse Monoclonal Antibody (LMO2/1971) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red)

Product Details

Synonyms

Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; RBTN L1; RBTN2; Rhombotin like 1; Rhombotin-2 (RHOM2); T-cell translocation protein 2; TTG2

Positive Control

K562, Ramos or Raji cells. Placenta, pancreas or Hodgkin s lymphoma.

Known Applications & Suggested Dilutions

Flow Cyt, Western Blot, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human LMO2 protein fragment (around aa 23-140) (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

24kDa

Specificity & Comments

The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin. LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkin s and Burkitt s lymphomas.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Younes, SF et al. Am J Clin Pathol. 2011 May;135(5):697-708.

Bioinformatics

  •  Entrez Gene ID: 4005
  •  Gene Symbol: LMO2
  •  SwissProt: P25791
  •  Chromosome Location: 11p13
  •  Unigene: 34560
NBT01971