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LMO2 (B-Cell Marker) Antibody [LMO2/1972]

Additional information

Catalog Number: 4005-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4005-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4005-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4005-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
LMO2 (B-Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human follicular lymphoma stained with LMO2 Mouse Monoclonal Antibody (LMO2/1972).

LMO2 (B-Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human pancreas stained with LMO2 Mouse Monoclonal Antibody (LMO2/1972).

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
LMO2/1972
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Nucleus
Gene Name
LMO2
Positive Control
K562, pancreas or Hodgkin s lymphoma, Ramos or Raji cells.Placenta
Immunogen
Recombinant human LMO2 protein fragment (around aa 23-140) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Key References
  • Younes, SF et al. Am J Clin Pathol. 2011 May;135(5):697-708.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4005
SwissProt
P25791
Chromosome Location
11p13
Mol. Weight of Antigen
24kDa
Alternate Names
Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, T-cell translocation protein 2, Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; RBTN L1; RBTN2;Rhombotinlike 1; Rhombotin-2 (RHOM2); T-cell translocation protein 2; TTG2

Summary

The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin.LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkin s and Burkitt s lymphomas.

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