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Home >> Antibodies >> HPV16 E2 (Human Papilloma Virus 16)

HPV16 E2 (Human Papilloma Virus 16)

Mouse Monoclonal Antibody [Clone TVG 261]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified Mouse Monoclonal Antibody HPV16 E2 (Human Papilloma Virus 16). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

HPV16 regulatory protein E2; Human papilloma virus 16 E2; Human papilloma virus 16 regulatory protein E2; Human papillomavirus type 16 E2; Human papillomavirus type 16 regulatory protein E2; Regulatory protein E2

Positive Control

HPV-16 infected cells. Cervical tissue.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2

Cellular Localization

Nuclear

Species Reactivity

Type 16 of Human Papilloma Virus (HPV-16)

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

43kDa

Specificity & Comments

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Hibma, M.H., et al. 1995. Eur. J. Biochem. 229: 517-525.

Bioinformatics

NBT03073