HPV16 E2 (Human Papilloma Virus 16) [TVG 261]



The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome.

Product Properties & Targets

Cellular Localization
Gene Name
Mol. Weight of Antigen
Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2

Database Links

Entrez Gene ID

Additional Information

TVG 261
Human Gene Symbol
Not Applicable
Chromosome Location
Not Applicable

Known Applications & Suggested Dilutions

  • Western Blot (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Hibma, M.H., et al. 1995. Eur. J. Biochem. 229: 517-525.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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