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Home >> Antibodies >> HPV16 E1/E4 (Human Papilloma Virus 16)

HPV16 E1/E4 (Human Papilloma Virus 16)

Mouse Monoclonal Antibody [Clone HPV16 E1/E4]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4).

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Formalin-fixed, paraffin-embedded human Cervix stained with HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4).

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SDS-PAGE Analysis Purified HPV-18 Mouse Monoclonal Antibody (HPV16 E1/E4). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

HPV-16; HPV-16 capsid; HPV16 L1; HPV16 major capsid protein L1; Human papillomavirus type 16 L1; Human papillomavirus type 16 major capsid protein L1

Positive Control

HPV-16 infected cells. Cervical tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human HPV16 E1/E4 fragment (aa 36-41).

Cellular Localization

Nuclear

Species Reactivity

Type 16 of Human Papilloma Virus (HPV-16).

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

16kDa

Specificity & Comments

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Reich, N.C., et al. 1983. Mol. Cell. Biol. 3: 2143-2150.

Bioinformatics

NBT03066