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Home >> Antibodies >> DBC2 / RHOBTB2

DBC2 / RHOBTB2

Mouse Monoclonal Antibody [Clone DBC2/3361]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified DBC2 Mouse Monoclonal Antibody (DBC2/3361). Confirmation of Purity and Integrity of Antibody.

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IHC analysis of formalin-fixed, paraffin-embedded human renal oncocytoma. Staining using DBC2/3361 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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IHC analysis of formalin-fixed, paraffin-embedded human thyroid. Staining using DBC2/3361 at 2ug/ml in PBS for 30min RT.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using DBC2 Mouse Monoclonal Antibody (DBC2/3361).

Product Details

Synonyms

Deleted in breast cancer 2 gene protein; p83; Rho related BTB domain containing protein 2

Positive Control

Human heart muscle or brain tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Human recombinant RHOBTB2 protein fragment (around aa 554-604) (exact sequence is proprietary)

Cellular Localization

Secreted in plasma

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

83kDa

Specificity & Comments

The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Ramos, S., et al. 2002. Gene 298: 147-157.

Bioinformatics

  •  Entrez Gene ID: 23221
  •  Gene Symbol: RHOBTB2
  •  SwissProt: Q9BYZ6
  •  Chromosome Location: 8p21.3
  •  Unigene: 372688