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Home >> Antibodies >> CA19-9/Sialyl Lewisa (GI Tumor Marker)

CA19-9/Sialyl Lewisa (GI Tumor Marker)

Recombinant Rabbit Monoclonal Antibody [Clone CA19.9/1390R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with CA19-9 Rabbit Recombinant Monoclonal Antibody (CA19.9/1390R).

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SDS-PAGE Analysis of Purified CA19-9 Rabbit Monoclonal Antibody (CA19.9/1390R).

Product Details

Synonyms

CA19.9, Ovarian tumor antigen, Pancreatic tumor antigen, Sialyl Lewis a

Positive Control

Stomach or Colon Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (5-10ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Purified human CA19-9 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

>400kDa

Specificity & Comments

CA19-9, a carbohydrate epitope expressed on a high MW (400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This MAb is excellent for staining of formalin-fixed, paraffin-embedded tissues.

Related Products



200ug/ml of Ab Purified by Protein A column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA and Azide at 1.0mg/ml.

Key References

  1. Blood transfusion and Immunohaematology, Ph. Rouger, D Anstee and Ch. Salmon (Eds). Arnette, France 30 (5): 353-720 (1987).
  2. Tumor Biol 19(5): 390420, (1998; TD-6 Workshop Report).

Bioinformatics

NBT01390