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Home >> Antibodies >> ACE2 / Angiotensin I Converting Enzyme 2

ACE2 / Angiotensin I Converting Enzyme 2

Recombinant Rabbit Monoclonal Antibody [Clone ACE2/6788R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified ACE2 / CD143 Rabbit Monoclonal Antibody (ACE2/6788R). Confirmation of Integrity and Purity of Antibody.

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IHC analysis of formalin-fixed, paraffin-embedded human small intestine. Stained using ACE2/6788R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

ACE related carboxypeptidase; ACE2; ACEH; Angiotensin converting enzyme 2; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin-converting enzyme homolog; EC 3.4.17; DKFZP434A014; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2

Positive Control

Human kidney, heart, testis or small intestine.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa705-805) of human ACE2 (exact sequence is proprietary)

Cellular Localization

Cell membrane. Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

92kDa

Specificity & Comments

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Donoghue M, et al. Circ. Res. 87:E1-E9 (2000).
  2. Hofmann H, et al. Natl. Acad. Sci. U.S.A. 102:7988-7993 (2005).

Bioinformatics

  •  Entrez Gene ID: 59272
  •  Gene Symbol: ACE2
  •  SwissProt: Q9BYF1
  •  Chromosome Location: Xp22.2
  •  Unigene: 178098