Angiotensin-Converting Enzyme 2 (ACE2) plays a critical role in the renin-angiotensin system. With a molecular weight of approximately 120 kDa, ACE2 is primarily expressed on the cell membrane, particularly on the surface of endothelial cells in the heart and lungs. Unlike its counterpart, angiotensin-converting enzyme (ACE), ACE2 is not secreted but remains anchored to the cell membrane. Posttranslational modifications, such as glycosylation, influence ACE2’s structure and function, affecting its enzymatic activity.
The main function of ACE2 is to regulate blood pressure by metabolizing angiotensin II into angiotensin-(1-7). This enzymatic conversion promotes vasodilation, counteracting the vasoconstrictive effects of angiotensin II. The expression of ACE2 is modulated by factors such as age, gender, and comorbidities, and it is noteworthy for its involvement in viral infections.
In human health and disease, ACE2 gained significant attention due to its role as the cellular receptor for the SARS-CoV-2 virus, responsible for the COVID-19 pandemic. The virus binds to ACE2 on the cell surface, facilitating viral entry into host cells, particularly in the respiratory system. The dysregulation of ACE2 expression and activity is implicated in the severity of COVID-19, making it a focal point for therapeutic interventions and research.
Antibodies targeting ACE2 have emerged as valuable tools in various applications. In the clinical realm, they find use in diagnostic assays, aiding in detecting and quantifying ACE2 levels. Additionally, ACE2 antibodies have potential applications in prognostic assessments, providing insights into disease progression and severity. As researchers delve deeper into understanding ACE2’s role in health and disease, these antibodies also hold promise for therapeutic interventions, guiding the development of targeted treatments.
At Neobiotechnologies, we are dedicated to providing high-quality antibodies for researchers and clinicians exploring ACE2 and its implications. Our extensive catalog offers reliable tools for various applications, ensuring the accuracy and precision needed for advancing knowledge and addressing critical health challenges.
Synonyms
Angiotensin-converting enzyme 2 | Processed angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15, ACE related carboxypeptidase; ACE2; ACEH; Angiotensin converting enzyme 2; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin-converting enzyme homolog; EC 3.4.17; DKFZP434A014; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2
Research Areas
Cardiovascular, Infectious Disease
