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Recombinant ACE2 / Angiotensin | Converting Enzyme 2 Antibody [ACE2/6788R]

These antibodies perform exceptionally well in the intended applications and have undergone stringent testing and additional validation to ensure monospecificity.

The MAbMan recommends these antibodies for repeatable and reliable results.

Additional information

Catalog Number: 59272-RBM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
59272-RBM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
59272-RBM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
59272-RBM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
ACE2 Antibody in SDS-PAGE

ACE2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified ACE2 / CD143 Rabbit Monoclonal Antibody (ACE2/6788R). Confirmation of Integrity and Purity of Antibody.

Recombinant ACE2 / Angiotensin | Converting Enzyme 2 Antibody - Image 2

IHC analysis of formalin-fixed, paraffin-embedded human small intestine. Stained using ACE2/6788R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

ACE2 Antibody in Immunohistochemistry (IHC (P))

ACE2 Antibody in Immunohistochemistry (IHC (P))

Normal Tissue & Cancer Tissue Galleries Expanded TMA showing antibody reactivity only with normal as well as cancer tissues expressing the intended target, all others are a negative control.

  • ELISA
  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
ELISA, Immunohistochemistry
Species Reactivity
Human
Clone
ACE2/6788R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Apical cell membrane, Cell membrane, Cell projection, Cilium, Cytoplasm, Secreted
Gene Name
ACE2
Positive Control
Heart, Human kidney, testis or small intestine.
Immunogen
Recombinant fragment (around aa705-805) of human ACE2 (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Reactivity:

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Reactivity:

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Additional information

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Reactivity:

Gene:

Host:

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Reactivity:

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Other Information

Functions
  • Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582).
  • Non-functional as a carboxypeptidase.
  • (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63.
  • (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.
Key References
  • Donoghue M, et al. Circ. Res. 87:E1-E9 (2000).
  • Hofmann H, et al. Natl. Acad. Sci. U.S.A. 102:7988-7993 (2005).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
59272
SwissProt
Q9BYF1
Chromosome Location
Xp22.2
Mol. Weight of Antigen
92kDa
Alternate Names
Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15, ACE related carboxypeptidase; ACE2; ACEH; Angiotensin converting enzyme 2; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin-converting enzyme homolog; EC 3.4.17; DKFZP434A014; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2

Summary

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

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