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Ornithine Decarboxylase-1 (ODC-1) Antibody [ODC1/485]

In Stock
Best Seller
Catalog Number Formulation Size Price
4953-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
4953-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
4953-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Ornithine Decarboxylase-1 Antibody in Antibody in Immunofluorescence (IF)

Ornithine Decarboxylase-1 Antibody in Antibody in Immunofluorescence (IF)

Confocal immunofluorescence image of LNCaP cells using AF488-labeled ODC-1 Mouse Monoclonal Antibody (ODC1/485) (green). Nuclei are counterstained with DAPI (blue).

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded mouse pancreas stained with ODC-1 Mouse Monoclonal Antibody (ODC1/485).

Ornithine Decarboxylase-1 Antibody in Western Blot (WB)

Ornithine Decarboxylase-1 Antibody in Western Blot (WB)

Western blot analysis of human placental tissue lysate using ODC-1 Mouse Monoclonal Antibody (ODC1/485).

Ornithine Decarboxylase-1 Antibody in SDS-PAGE

Ornithine Decarboxylase-1 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified ODC-1 Mouse Monoclonal Antibody (ODC1/485). Confirmation of Purity and Integrity of Antibody.

Ornithine Decarboxylase-1 Antibody in Flow Cytometry (FC)

Ornithine Decarboxylase-1 Antibody in Flow Cytometry (FC)

Flow cytometric analysis of human ODC-1 in PC3 cells. Black: cells alone; Grey: Isotype Control; Green: AF488-labeled ODC-1 Mouse Monoclonal Antibody (ODC1/485).

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with ODC-1 Mouse Monoclonal Antibody (ODC1/485).

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with ODC-1 Mouse Monoclonal Antibody (ODC1/485).

Ornithine Decarboxylase-1 Antibody in Western Blot (WB)

Ornithine Decarboxylase-1 Antibody in Western Blot (WB)

Western blot analysis of PC3 cell lysate using ODC-1 Mouse Monoclonal Antibody (ODC1/485).

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Ornithine Decarboxylase-1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded rat pancreas stained with ODC1 Mouse Monoclonal Antibody (ODC1/485).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human, Mouse, Rat
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Cytosol
Gene Name
ODC1
Positive Control
Epithelial cells in normal placenta or prostate carcinoma. LNCaP or PC3 cells.
Immunogen
Recombinant full-length human ODC-1 protein
Alternate Names
Ornithine decarboxylase, Ornithine decarboxylase structural 1; RNODC

Database Links

Entrez Gene ID
4953
SwissProt
P11926

Additional Information

Clone
ODC1/485
Chromosome Location
2p25.1
Mol. Weight of Antigen
53kDa.

Related Antibodies

View All ODC1 Antibodies

Functions

  • Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Key References

  • Schipper RG; et al. Journal of Immunological Methods, 1993, 161(2):205-15.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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