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Mannose Receptor / CD206 Antibody [MRC1/9454]

In Stock
Catalog Number Formulation Size Price
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes


CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of
the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Product Properties & Targets

Antibody Type
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Gene Name
Recombinant fragment (around aa1100-1400) of human MRC1 protein (exact sequence is proprietary)
Alternate Names
macrophage mannose receptor 1, bA541I19.1 antibody; C type lectin domain family 13 member; D antibody C-type lectin domain family 13 member D antibody; CD 206 antibody; CD206 antibody; CD206 antigen antibody; CLEC13D antibody; CLEC13DL antibody; Macrophage mannose receptor 1 antibody; Macrophage mannose receptor 1 like protein 1 antibody; Macrophage mannose receptor antibody; Mannose receptor C type 1 antibody; Mannose receptor C type 1 like 1 antibody; MMR antibody; MRC 1 antibody; MRC1 antibody; MRC1_HUMAN antibody; MRC1L1 antibody; OTTHUMP00000045206 antibody, C-type lectin domain family 13 member D; human mannose receptor; macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1-like 1

Database Links

Entrez Gene ID

Additional Information

Chromosome Location
Mol. Weight of Antigen


  • Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Key References

  • Sanchez-Moral, L., Paul, T., et al. (2023). Macrophage CD5L is a target for cancer immunotherapy. EBioMedicine, 91, 104555. https://doi.org/10.1016/j.ebiom.2023.104555
  • Yang, H., Yan, M., Li, W., & Xu, L. (2022). SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma. Journal of translational medicine, 20(1), 140. https://doi.org/10.1186/s12967-022-03342-6
  • Tong, L., Li, J., Li, Q., et al. (2020). ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. Theranostics, 10(13), 5943–5956. https://doi.org/10.7150/thno.41498
  • Kosmac, K., Peck, B. D., et al. (2018). Immunohistochemical Identification of Human Skeletal Muscle Macrophages. Bio-protocol, 8(12), e2883. https://doi.org/10.21769/BioProtoc.2883

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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