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ERG (Vascular Endothelial & Prostate Marker) Antibody [ERG/2107]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
2078-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2078-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2078-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The transcription factor erythroblastosis virus E26 transforming sequence related gene (ERG) functions as a regulator of key cellular functions to promote endothelial homeostasis.Expression of ERG has been observed in both benign and malignant vascular endothelial tumors, such as hemangiomas and Kaposi sarcomas, respectively.Carcinomas of the breast, colon, and urothelium have demonstrated absence of ERG expression, whereas presence of the protein has been confirmed in a subset of prostate carcinoma cases.Anti-ERG can be a useful tool for identifying vascular endothelial neoplasms and distinguishing prostate carcinoma from epithelial tumors of non-prostatic origin.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
ERG
Positive Control
Ewing sarcoma or prostate adenocarcinoma tissues., HUVEC cells. Human tonsil
Immunogen
Recombinant human full-length ERG protein
Alternate Names
Transcriptional regulator ERG, Transforming protein ERG, ERG; ERG/EWS fusion gene; ERG/FUS fusion gene; ERG/TMPSSR2 fusion gene; ERG1; ETS-related; KCNH2; Oncogene ERG; p55; TMPRSS2/ERG fusion

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
ERG/2107
Chromosome Location
21q22.2
Mol. Weight of Antigen
55kDa

Functions

  • Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Key References

  • Miettinen M, et al. ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma. American Journal of Surgical Pathology 35, 432-441 (2011).

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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