SDS-PAGE Analysis Purified CDw78 Monoclonal Antibody (DF1588). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis Purified CDw78 Monoclonal Antibody (DF1588). Confirmation of Purity and Integrity of Antibody.

CDw78 [DF1588]

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Summary

Reacts with a carbohydrate determinant, identified as CDw78 (Workshop V; Code CDw78.2). Epitope recognized by this MAb and Leu21 is the same. It is present on some immature and some peripheral blood B cells, and some B cell lines. Its expression is increased after B-cell activation in vitro. CDw78 is also found on tissue macrophages and on epithelial cells, but not on T cells, NK cells, monocytes, granulocytes and myeloid tissues. It appears that CDw78 is a determinant on a major histocompatibility complex (MHC) class II subpopulation.

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Product Properties & Targets

Host
Mouse
Species Reactivity
Human
Isotype
IgG1
Cellular Localization
N/A
Gene Name
N/A
Mol. Weight of Antigen
Not Known
Immunogen
Human leucocytes

Database Links

Entrez Gene ID
Not Known
Unigene
Not Known
SwissProt
N/A

Additional Information

Clone
DF1588
Human Gene Symbol
Not Known
Chromosome Location
Not Known

Known Applications & Suggested Dilutions

  • Functional Studies (Order Ab without Azide)
  • Flow Cytometry (1-2ug/million cells)
  • Immunofluorescence (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Kikutani H et al. Expression and function of an early activation marker restricted to human B cells. J Immunol 1986, 136(11):4019-4026.
  • Schlossman SF et al. Leukocyte Typing V, p604-606, Oxford University Press, Oxford, 1995.
  • Slack JL et al. Molecular characterization of the pan-B cell antigen CDw78 as a MHC class II molecule by direct expression cloning of the transcription factor CIITA. Int Immunol 1995, 7(7):1087-1092.
  • Knapp W et al. Leukocyte Typing IV, p122, p155-162 and p165-174, Oxford University Press, Oxford, 1989.
  • Rasmussen AM et al. CDw78--a determinant on a major histocompatibility complex class II subpopulation that can be induced to associate with the cytoskeleton. Eur J Immunol 1997, 27(12):3206-3213.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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