CD195 (CC-Chemokine Receptor 5) [12D1]



Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Product Properties & Targets

Species Reactivity
Research Areas
Cellular Localization
Cell membrane
Light Chain
Gene Name
Positive Control
HeLa, U87 or MCF-7 cells. Human lymph node and tonsil.
Human native CCR5 protein
Alternate Names
C-C chemokine receptor type 5, CHEMR13, HIV-1 fusion coreceptor, CC Chemokine Receptor Type 5; CC-CKR-5; CCCKR5; CCR5; Chemokine CC motif receptor 5; Chemokine receptor CCR5; CHEMR13; CKR5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; MIP-1 alpha receptor

Database Links

Entrez Gene ID

Additional Information

Human Gene Symbol
Chromosome Location
Mol. Weight of Antigen


  • Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770).
  • (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.

Known Applications & Suggested Dilutions

  • Immunofluorescence (1-2ug/ml)
  • Flow Cytometry (1-2ug/million cells)
  • Immunohistochemistry (Frozen) (1-2ug/ml for 30 minutes at RT)Optimal dilution for a specific application should be determined.

Key References

  • Samson M, et al. 1996. Biochemistry 35:3362.2. Raport CJ, et al. 1996. J. Biol. Chem. 271:17161.3. Combadiere C, et al. 1996. J. Leukoc. Biol. 60:147.4. Deng H, et al. 1996. Nature 381:661.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


There are no reviews yet.

Be the first to review “CD195 (CC-Chemokine Receptor 5)”

Your email address will not be published. Required fields are marked *

Recombinant mouse monoclonal antibodies and recombinant rabbit monoclonals to support your research

Shop Primary Antibodies