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CD161 / KLRB1 (Killer cell lectin like receptor B1) Antibody [KLRB1/8910]

Additional information

Catalog Number: 3820-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3820-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3820-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3820-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD161 / KLRB1 (Killer cell lectin like receptor B1) Antibody

Formalin-fixed, paraffin-embedded human prostate stained with CD161 Mouse Monoclonal Antibody (KLRB1/8910). Inset: PBS instead of primary antibody; secondary only negative control.

CD161 / KLRB1 (Killer cell lectin like receptor B1) Antibody - Image 2

SDS-PAGE Analysis of Purified CD161 Mouse Monoclonal Antibody (KLRB1/8910). Confirmation of Purity and Integrity of Antibody.

CD161 Antibody in Western Blot (WB)

CD161 Antibody in Western Blot (WB)

Western Blot Analysis of human Spleen tissue lysate using CD161 Mouse Monoclonal Antibody (KLRB1/8910).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
KLRB1/8910
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Membrane. Cytoplasm.
Gene Name
KLRB1
Positive Control
Human prostate|kidney, Spleen or thyroid cancer tissue.
Immunogen
Recombinant fragment (around aa1-225) of human KLRB1 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1, 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Key References
  • Sentman, C.L., et al. 1989. Pan natural killer cell monoclonal antibodies and their relationship to the NK-1.1 antigen. Hybridoma 8: 605-614.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3820
SwissProt
Q12918
Chromosome Location
12p13.31
Mol. Weight of Antigen
25kDa
Alternate Names
Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, Natural killer cell surface protein P1A, C-type lectin domain family 5 member B; CD161; CLEC5B; HNKR-P1a; Killer Cell Lectin like Receptor Subfamily B Member 1; KLRB1; Natural killer cell surface protein P1A; NKR; NKRP1; NKRP1A

Summary

Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. T cells bearing natural killer receptors (NKRs) such as CD94 and CD161 are present in psoriasis. CD161 mediates NK cell activation and functions as an activating receptor. CD161 is a prototypic marker of NK cells, although it is also found on a subset of CD8+ T cells. The expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector T cells that are expanded in vivo after antigenic activation leading to extensive proliferation. The transcription, mRNA accumulation, and surface expression of CD161, a molecule involved in triggering cytotoxicity, is specifically upregulated by IL-12.

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