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Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with Bax Mouse Monoclonal Antibody (2D2).
Flow Cytometric Analysis of human Jurkat cells using Bax Mouse Monoclonal Antibody (2D2) followed by Goat anti-Mouse IgG-CF488 (Orange); cells alone (Blue); Isotype Control (Red).
Confocal Immunofluorescence of Human Jurkat cells A. Bax Mouse Monoclonal Antibody (Clone 2D2) B. Goat anti Mouse CF488. labeled with CF488 (Green); Reddot is used to label the nuclei.
Recognizes a protein of 21kDa, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
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