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Home >> Antibodies >> Vitronectin Receptor / CD51 / CD61

Vitronectin Receptor / CD51 / CD61

Mouse Monoclonal Antibody [Clone 23C6]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified Vitronectin Receptor Mouse Monoclonal Antibody (23C6). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CD51; DKFZp686A08142; integrin alpha V beta 3; Integrin alpha-5 Integrin alpha-V light chain; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITGAV; Msk8; VNRA; VTNR

Positive Control

Squamous cells, A375M melanoma cells. A549 cells.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order antibody without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Osteoclasts from osteoclastomas

Cellular Localization

Cell Surface

Species Reactivity

Human. Chicken. Does not react with Bovine or Pig or Rabbit.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

150-160kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130kDa +20-25kDa.

Specificity & Comments

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kotake, S et al. Cell Biol Int. 2013 Jan;37(1):65-77.

Bioinformatics

  •  Entrez Gene ID: 3685
  •  Gene Symbol: ITGAV
  •  SwissProt: P06756
  •  Chromosome Location: 2q32.1
  •  Unigene: 436873
NBT01471