CD51 / Integrin V [ITGAV/1610]

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Summary

Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Product Properties & Targets

Host
Species Reactivity
Isotype
Cellular Localization
Gene Name
ITGAV
Mol. Weight of Antigen
150-160kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130kDa +20-25kDa.
Immunogen
Recombinant human full-length integrin alpha V beta 1 protein

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
ITGAV/1610
Human Gene Symbol
ITGAV
Chromosome Location
2q32.1

Known Applications & Suggested Dilutions

  • ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA)
  • Flow Cytometry (1-2ug/million cells)
  • Immunofluorescence (1-2ug/ml)
  • Western Blot (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Nilsson, M., et al. 2004. J. Gene Med. 6: 631-641.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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