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Home >> Antibodies >> TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor)

TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor)

Recombinant Rabbit Monoclonal Antibody [Clone VEGI/2052R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human Spleen stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).

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Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).

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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with VEGI Rabbit Recombinant Monoclonal Antibody (VEGI /2052R).

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SDS-PAGE Analysis Purified VEGI Rabbit Monoclonal Antibody (VEGI /2052R). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using VEGI Rabbit Recombinant Monoclonal Antibody (VEGI/2052R).

Product Details

Synonyms

TNF ligand-related molecule 1 (TL1A); Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15); Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor (VEGI); VEGI192A

Positive Control

Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen and prostate.

Known Applications & Suggested Dilutions

Immunohistology         More Details

Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human VEGI protein

Cellular Localization

Secreted and Cell Surface

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

22kDa

Specificity & Comments

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Related Products



200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Parr C,et al. Angiogenesis.2006;9(2):73-81.
  2. Zhai, Y., et al. 1999. Int. J. Cancer 82: 131-136. 5.
  3. Zhai, Y., et al. 1999.. FASEB J. 13: 181-189.

Bioinformatics

  •  Entrez Gene ID: 9966
  •  Gene Symbol: TNFSF15
  •  SwissProt: O95150
  •  Chromosome Location: 9q32
  •  Unigene: 241382