Learn about our comprehensive antibody validation methods to ensure monospecificity.  Antibody Validation>>

Recombinant TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Antibody [VEGI/2052R]

In Stock
Catalog Number Formulation Size Price
9966-RBM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
9966-RBM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
9966-RBM2-P1ABX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Membrane, Secreted
Gene Name
Positive Control
Endothelial cells. Colon, intestine, Kidney, Liver, Lung, Pancreas, Placenta, spleen and prostate.
Immunogen
Recombinant full-length human VEGI protein
Alternate Names
Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, TNF ligand-related molecule 1 (TL1A); Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15); Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor (VEGI); VEGI192A

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
VEGI/2052R
Chromosome Location
9q32
Mol. Weight of Antigen
22kDa

Functions

  • Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Key References

  • Parr C,et al. Angiogenesis.2006;9(2):73-81.
  • Zhai, Y., et al. 1999. Int. J. Cancer 82: 131-136. 5.
  • Zhai, Y., et al. 1999.. FASEB J. 13: 181-189.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Reviews

There are no reviews yet.

Be the first to review “Recombinant TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Antibody”

Your email address will not be published. Required fields are marked *

PARTNERSHIP OPPORTUNITIES

We hold Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK