Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Thrombomodulin / CD141 Monoclonal Antibody (rTHBD/1591).
Formalin-fixed, paraffin-embedded human Placenta stained with Thrombomodulin / CD141 Monoclonal Antibody (rTHBD/1591).
SDS-PAGE Analysis Purified Thrombomodulin Mouse Recombinant Monoclonal Antibody (rTHBD/1591). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing >19,000 full-length human proteins using Thrombomodulin Recombinant Mouse Monoclonal Antibody (rTHBD/1591)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi's sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.