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Home >> Antibodies >> STAT6 (Solitary Fibrous Tumor Marker)

STAT6 (Solitary Fibrous Tumor Marker)

Mouse Monoclonal Antibody [Clone STAT6/2410]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with STAT6 Mouse Monoclonal Antibody (STAT6/2410).

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SDS-PAGE Analysis Purified STAT6 Mouse Monoclonal Antibody (STAT6/2410). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using STAT6 Mouse Monoclonal Antibody (STAT6/2410)

Product Details

Synonyms

IL4 STAT; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; STAT interleukin4 induced; STAT6; Transcription factor IL 4 STAT

Positive Control

HeLa or HepG2 cells. Kidney.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human STAT6 protein

Cellular Localization

Cytoplasmic & Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

119kDa

Specificity & Comments

STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Hou, J., et al. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265: 1701-1706.

Bioinformatics

  •  Entrez Gene ID: 6778
  •  Gene Symbol: STAT6
  •  SwissProt: P42226
  •  Chromosome Location: 12q13.3
  •  Unigene: 524518
NBT02410