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Home >> Antibodies >> Spastin

Spastin

Mouse Monoclonal Antibody [Clone Sp 6C6]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Western Blot Analysis of human K-562 cell lysates using Spastin Mouse Monoclonal Antibody (Sp 6C6).

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Western Blot Analysis of human Raji cell lysates using Spastin Mouse Monoclonal Antibody (Sp 6C6).

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SDS-PAGE Analysis Purified Spastin Mouse Monoclonal Antibody (Sp 6C6). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

ADPSP; FSP2; Spast; Spatin; SPG4

Positive Control

HeLa cells. K-562 or Raji cell lysates.

Known Applications & Suggested Dilutions

IF, Western Blot         More Details

Immunofluorescence (1-2ug/ml)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Spastin protein.

Cellular Localization

Cell Membrane and Secreted.

Species Reactivity

Human. Mouse. Rat.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

52kDa

Specificity & Comments

The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Daftary et al. 2011. Mol Endocrinol. 25(9):1539-49. PMID: 21757506.

Bioinformatics

  •  Entrez Gene ID: 6683
  •  Gene Symbol: SPAST
  •  SwissProt: Q9UP0
  •  Chromosome Location: 2p22.3
  •  Unigene: 468091
NBT03070