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Home >> Antibodies >> S100A4 / Metastasin / Calvasculin (Marker of Tumor Metastasis)

S100A4 / Metastasin / Calvasculin (Marker of Tumor Metastasis)

Mouse Monoclonal Antibody [Clone CPTC-S100A4-3]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Analysis of Protein Array containing more than 19,000 full-length human proteins using S100A4 Mouse Monoclonal Antibody (CPTC-S100A4-3).

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SDS-PAGE Analysis Purified S100A4 Mouse Monoclonal Antibody (CPTC-S100A4-3). Confirmation of Purity and Integrity of Antibody

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Flow Cytometric Analysis of T98G cells using S100A4 Mouse Monoclonal Antibody (CPTC-S100A4-3) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

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Immunofluorescence Analysis of T98G cells labeling S100A4 with S100A4 Mouse Monoclonal Antibody (CPTC-S100A4-3) followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).

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Flow Cytometric Analysis of A549 cells using S100A4 Mouse Monoclonal Antibody (CPTC-S100A4-3) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Product Details

Synonyms

S100 calcium-binding protein A4; Calvasculin; CAPL; Fibroblast specific protein 1 (FSP1); Leukemia multidrug resistance associated protein; Malignant transformation suppression 1 (MTS1); Metastasin; Placental calcium-binding protein

Positive Control

T98G, HeLa, A549 or A375 cells. Placenta, small intestine.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Western Blot         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human S100A4 full length protein

Cellular Localization

Nucleus and cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

12kDa

Specificity & Comments

S100A4 belongs to the S100 super-family of proteins containing 2 EF-hand calcium-binding domains. S100A4 has been implicated in the progression and prognosis of several forms of human cancer, e.g. breast, colorectal, gastric, pancreatic and bladder cancer, SCLC and oesophageal squamous cell carcinoma, among others. Poor prognosis associated with high S100A4 expression is accompanied by clear signs of disease progression, e.g. high histological and clinical grades and involvement of lymph nodes.Also indicative of poor prognosis is high S100A4 expression coupled with reduced E-cadherin expression in pancreatic, oral squamous cell carcinoma and in melanoma. S100A4 expression is inversely related with expression of metastasis suppressor nm23 and with prognosis of breast cancer. S100A4 is overexpressed in highly metastatic cancers, which makes it useful as a marker of tumor progression.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Orre, L M, et al. Nature News, Nature Publishing Group, 10 June 2013.

Bioinformatics

  •  Entrez Gene ID: 6275
  •  Gene Symbol: S100A4
  •  SwissProt: P26447
  •  Chromosome Location: 1q21.3
  •  Unigene: 654444
NBT02224