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Home >> Antibodies >> p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker)

p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker)

Biotinylated Recombinant Rabbit Monoclonal Antibody [Clone TP40/3980R]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab conjugated to Biotin

Catalog No


0.5 ml at 100ug/ml


Purified Ab conjugated to Biotin

Price (USD)


Formalin-fixed, paraffin-embedded human prostate stained with Biotinylated p40 Recombinant Rabbit Monoclonal Antibody (TP40/3980R).

Product Details


deltaNp63, TP63

Positive Control

HeLa cells. Human prostate or lung tissue (IHC).

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details

Flow Cytometry (2-4ug/million cells)
Immunofluorescence (2-4ug/ml)
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °
C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.


A synthetic peptide from the N-terminal of human p40protein (Exact sequence is proprietary)

Cellular Localization


Species Reactivity


Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen


Specificity & Comments

p63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. P40/3980R recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.

Related Products

200ug/ml of Ab purified by Protein A Column and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Signoretti S, et al. Am J Pathol. 2000; 157(6):1769-75.
  2. Terry J, et al. Am J Surg Pathol. 2010; 34(12):1805-11.


  •  Entrez Gene ID: 8626
  •  Gene Symbol: TP63
  •  SwissProt: Q9H3D4
  •  Chromosome Location: 3q28
  •  Unigene: 137569