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Home >> Antibodies >> Ornithine Decarboxylase-1 (ODC-1)

Ornithine Decarboxylase-1 (ODC-1)

Mouse Monoclonal Antibody [Clone ODC1/487]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

IF staining of LNCap cells using AF488 labeled ODC1 Monoclonal Antibody (ODC1/487) (Green). DAPI was used to stain the cell nuclei (blue).

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Formalin-fixed, paraffin-embedded Rat Pancreas stained with ODC1 Monoclonal Antibody (ODC1/487)

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Formalin-fixed, paraffin-embedded Mouse Pancreas stained with ODC1 Monoclonal Antibody (ODC1/487)

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Formalin-fixed, paraffin-embedded Mouse Small Intestine stained with ODC1 MAb (ODC1/487)

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SDS-PAGE Analysis Purified ODC1 MAb (ODC1/487). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Ornithine decarboxylase structural 1; RNODC

Positive Control

PC3 cells. Placenta, Prostate or Testicular carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Western Blot, IHC-P         More Details

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human ODC-1 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Mouse. Rat.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

53kDa

Specificity & Comments

Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Schipper RG; Rutten RG; Sauerbeck M; Schielen WJ; Adams PJ; Kopitz J; Bohley P; Tesser GI; Verhofstad AA. Preparation and characterization of monoclonal antibodies against ornithine decarboxylase. Journal of Immunological Methods, 1993, 161(2):205-15.

Bioinformatics

  •  Entrez Gene ID: 4953
  •  Gene Symbol: ODC1
  •  SwissProt: P11926
  •  Chromosome Location: 2p25.1
  •  Unigene: 467701
NBT00487