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Home >> Antibodies >> Ornithine Decarboxylase-1 (ODC-1)

Ornithine Decarboxylase-1 (ODC-1)

Mouse Monoclonal Antibody [Clone ODC1/485]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

459.00

Formulation

Purified Ab conjugated to CF488

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to CF488

Price (USD)

459.00
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Flow Cytometry of human ODC1 on PC3 cells. Black: cells alone; Grey: Isotype Control; Green: CF488-labeled ODC1 Monoclonal Antibody (ODC1/485).

Product Details

Synonyms

Ornithine decarboxylase structural 1; RNODC

Positive Control

Epithelial cells in normal placenta or prostate carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human ODC-1 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

53kDa

Specificity & Comments

Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

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Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Schipper RG; Rutten RG; Sauerbeck M; Schielen WJ; Adams PJ; Kopitz J; Bohley P; Tesser GI; Verhofstad AA. Preparation and characterization of monoclonal antibodies against ornithine decarboxylase. Journal of Immunological Methods, 1993, 161(2):205-15.

Bioinformatics

  •  Entrez Gene ID: 4953
  •  Gene Symbol: ODC1
  •  SwissProt: P11926
  •  Chromosome Location: 2p25.1
  •  Unigene: 467701
NBT00485