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Home >> Antibodies >> Moesin

Moesin

Mouse Monoclonal Antibody [Clone SPM562]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Melanoma stained with Moesin Mouse Monoclonal Antibody (SPM295)

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Western Blot Analysis of PC3 cell lysate. Moesin Mouse Monoclonal Antibody (SPM562).

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Immunofluorescence Analysis of PFA fixed HeLa cells labeling Moesinwith Moesin Mouse Monoclonal Antibody (SPM562) followed by Goat anti-mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).

Product Details

Synonyms

Membrane-organizing extension spike protein; Moesin/anaplastic lymphoma kinase fusion protein; MSN/ALK fusion

Positive Control

PC3, HeLa, HT-29, CH3LC or HUVEC cells. Uterus, Placenta, Tonsil, Melanoma, Testicular Carcinoma.

Known Applications & Suggested Dilutions

Western Blot, IF, IHC-P         More Details

Western Blot(1-2ug/ml)
Immunofluorescence (2-4ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Moesin Purified from uterus

Cellular Localization

Cytoplasmic & Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

78kDa

Specificity & Comments

Recognizes 78kDa moesin protein. Moesin, a member of the talin-4.1 superfamily, is a linking protein of the sub-membranous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lankes W et. al., Biochem Journal, 1988; 251:831-842.
  2. Schwartz-Albiez R et. al., European Journal Cell Biology, 1995; 67:189-198.

Bioinformatics

  •  Entrez Gene ID: 4478
  •  Gene Symbol: MSN
  •  SwissProt: P26038
  •  Chromosome Location: Xq11.1
  •  Unigene: 87752
NBT00491